Drug interactions
Celecoxib + Fluoxetine
Severity: Moderate
Celecoxib and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2C9 and may increase celecoxib exposure, while celecoxib may modestly raise fluoxetine levels via CYP2D6 inhibition. In addition, SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Celecoxib and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Fluoxetine belongs to Central Nervous System.
Why it happens
Mutual CYP inhibition (fluoxetine on CYP2C9, celecoxib on CYP2D6) plus additive impairment of platelet function and mucosal protection.
What to do
Use the lowest effective celecoxib dose and consider proton pump inhibitor cover in at-risk patients. Monitor for celecoxib adverse effects and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Celecoxib with Fluoxetine?
MediHelp rates the interaction as moderate. Celecoxib and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2C9 and may increase celecoxib exposure, while celecoxib may modestly raise fluoxetine levels via CYP2D6 inhibition. In addition, SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding.
How serious is the interaction between Celecoxib and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective celecoxib dose and consider proton pump inhibitor cover in at-risk patients. Monitor for celecoxib adverse effects and bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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