Drug interactions
Celecoxib + Fosinopril-hydrochlorothiazide
Severity: Moderate
Celecoxib and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can blunt the blood pressure lowering effect of the ACE inhibitor and diuretic. In patients who are older, volume depleted or have reduced kidney function, the triple effect of an NSAID, ACE inhibitor and diuretic can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Celecoxib and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces vasodilation and sodium excretion, opposing ACE inhibitor and thiazide effects and lowering glomerular filtration.
What to do
Prefer a non-NSAID analgesic such as paracetamol where possible. If the combination is required, use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Celecoxib and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can blunt the blood pressure lowering effect of the ACE inhibitor and diuretic. In patients who are older, volume depleted or have reduced kidney function, the triple effect of an NSAID, ACE inhibitor and diuretic can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Celecoxib and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol where possible. If the combination is required, use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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