Drug interactions
Celecoxib + Hydrocodone
Severity: Minor
Celecoxib and Hydrocodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak to moderate CYP2D6 inhibitor and could modestly alter hydrocodone conversion to hydromorphone. The clinical effect is small, since hydrocodone itself is active and is also cleared by CYP3A4.
What this interaction means in plain words
Celecoxib and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Hydrocodone belongs to Musculoskeletal.
Why it happens
Weak inhibition of CYP2D6 by celecoxib may slightly reduce O-demethylation of hydrocodone to hydromorphone.
What to do
No routine adjustment is needed. Monitor analgesic response and opioid adverse effects when celecoxib is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Hydrocodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Celecoxib with Hydrocodone?
MediHelp rates the interaction as minor. Celecoxib and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak to moderate CYP2D6 inhibitor and could modestly alter hydrocodone conversion to hydromorphone. The clinical effect is small, since hydrocodone itself is active and is also cleared by CYP3A4.
How serious is the interaction between Celecoxib and Hydrocodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor analgesic response and opioid adverse effects when celecoxib is started or stopped.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
