Drug interactions
Celecoxib + Mexiletine
Severity: Moderate
Celecoxib and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is partly metabolised by CYP2D6, so celecoxib may raise its levels. Mexiletine has a narrow therapeutic index with neurological and cardiac toxicity.
What this interaction means in plain words
Celecoxib and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Mexiletine belongs to Cardiovascular.
Why it happens
Celecoxib inhibits CYP2D6, reducing mexiletine metabolism.
What to do
Monitor for tremor, dizziness, nausea and arrhythmia, and consider mexiletine level monitoring. Reduce the mexiletine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Celecoxib with Mexiletine?
MediHelp rates the interaction as moderate. Celecoxib and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mexiletine is partly metabolised by CYP2D6, so celecoxib may raise its levels. Mexiletine has a narrow therapeutic index with neurological and cardiac toxicity.
How serious is the interaction between Celecoxib and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, dizziness, nausea and arrhythmia, and consider mexiletine level monitoring. Reduce the mexiletine dose if toxicity occurs.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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