Drug interactions
Celecoxib + Milnacipran
Severity: Moderate
Celecoxib and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin-norepinephrine reuptake inhibitors impair platelet serotonin uptake and, with an NSAID, raise the risk of bleeding, especially upper GI bleeding. Milnacipran may also raise blood pressure.
What this interaction means in plain words
Celecoxib and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Additive effects on haemostasis: reduced platelet serotonin and NSAID-induced mucosal injury and platelet inhibition.
What to do
Monitor for GI bleeding signs and consider gastroprotection in high-risk patients. Use the lowest effective celecoxib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Celecoxib with Milnacipran?
MediHelp rates the interaction as moderate. Celecoxib and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin-norepinephrine reuptake inhibitors impair platelet serotonin uptake and, with an NSAID, raise the risk of bleeding, especially upper GI bleeding. Milnacipran may also raise blood pressure.
How serious is the interaction between Celecoxib and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and consider gastroprotection in high-risk patients. Use the lowest effective celecoxib dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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