Drug interactions
Celecoxib + Nebivolol
Severity: Moderate
Celecoxib and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib inhibits CYP2D6 and may raise nebivolol levels, with potential bradycardia and hypotension. NSAIDs may also blunt its antihypertensive effect.
What this interaction means in plain words
Celecoxib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by celecoxib reduces nebivolol clearance, while NSAID prostaglandin inhibition opposes blood pressure lowering.
What to do
Monitor heart rate and blood pressure when celecoxib is started or stopped. Adjust the nebivolol dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Celecoxib with Nebivolol?
MediHelp rates the interaction as moderate. Celecoxib and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib inhibits CYP2D6 and may raise nebivolol levels, with potential bradycardia and hypotension. NSAIDs may also blunt its antihypertensive effect.
How serious is the interaction between Celecoxib and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when celecoxib is started or stopped. Adjust the nebivolol dose according to response.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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