Drug interactions
Celecoxib + Oxaprozin
Severity: Major
Celecoxib and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. Platelet effects and fluid retention may be additive.
What this interaction means in plain words
Celecoxib and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition causes duplicated pharmacodynamic toxicity on gastric mucosa, kidney and cardiovascular system.
What to do
Avoid concurrent use of two NSAIDs; choose a single agent at the lowest effective dose. Add gastroprotection if NSAID therapy is needed in a high-risk patient.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Oxaprozin?
MediHelp rates the interaction as major. Celecoxib and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. Platelet effects and fluid retention may be additive.
How serious is the interaction between Celecoxib and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs; choose a single agent at the lowest effective dose. Add gastroprotection if NSAID therapy is needed in a high-risk patient.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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