Drug interactions
Celecoxib + Oxymorphone
Severity: Minor
Celecoxib and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is cleared mainly by glucuronidation rather than CYP2D6, so celecoxib is not expected to change its exposure meaningfully. There is no established clinically important interaction.
What this interaction means in plain words
Celecoxib and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Celecoxib weakly inhibits CYP2D6, which is not a major clearance route for oxymorphone.
What to do
No adjustment is needed; monitor routinely for opioid effects and NSAID adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Celecoxib with Oxymorphone?
MediHelp rates the interaction as minor. Celecoxib and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymorphone is cleared mainly by glucuronidation rather than CYP2D6, so celecoxib is not expected to change its exposure meaningfully. There is no established clinically important interaction.
How serious is the interaction between Celecoxib and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor routinely for opioid effects and NSAID adverse effects.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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