Drug interactions
Celecoxib + Paclitaxel
Severity: Minor
Celecoxib and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib has been proposed to raise paclitaxel exposure through CYP2C8 inhibition, but celecoxib is not a clinically important CYP2C8 inhibitor. The interaction is largely theoretical, though NSAIDs may add to hematologic and gastrointestinal risk during chemotherapy.
What this interaction means in plain words
Celecoxib and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Paclitaxel belongs to Oncology.
Why it happens
Possible weak CYP2C8 inhibition by celecoxib, which is not well established clinically.
What to do
No dose adjustment is required; monitor blood counts and neurotoxicity as usual during paclitaxel therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Celecoxib with Paclitaxel?
MediHelp rates the interaction as minor. Celecoxib and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib has been proposed to raise paclitaxel exposure through CYP2C8 inhibition, but celecoxib is not a clinically important CYP2C8 inhibitor. The interaction is largely theoretical, though NSAIDs may add to hematologic and gastrointestinal risk during chemotherapy.
How serious is the interaction between Celecoxib and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor blood counts and neurotoxicity as usual during paclitaxel therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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