Drug interactions
Celecoxib + Phentolamine
Severity: Minor
Celecoxib and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the blood pressure lowering effect of vasodilating antihypertensives through sodium and fluid retention. For phentolamine, which is mostly used acutely, the effect is theoretical and unlikely to matter.
What this interaction means in plain words
Celecoxib and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandins and sodium retention by celecoxib may oppose alpha-blocker vasodilation.
What to do
No action is generally needed; check blood pressure response if phentolamine is used regularly alongside an NSAID.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Celecoxib with Phentolamine?
MediHelp rates the interaction as minor. Celecoxib and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce the blood pressure lowering effect of vasodilating antihypertensives through sodium and fluid retention. For phentolamine, which is mostly used acutely, the effect is theoretical and unlikely to matter.
How serious is the interaction between Celecoxib and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; check blood pressure response if phentolamine is used regularly alongside an NSAID.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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