Drug interactions
Celecoxib + Pivmecillinam
Severity: Minor
Celecoxib and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins are renally secreted by organic anion transport and NSAIDs may compete for this pathway, but pivmecillinam is a short-course agent with a wide safety margin. No clinically important effect is expected.
What this interaction means in plain words
Celecoxib and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular anion secretion and protein binding, of little clinical consequence.
What to do
No dose adjustment is needed; monitor renal function in patients with kidney impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Celecoxib with Pivmecillinam?
MediHelp rates the interaction as minor. Celecoxib and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins are renally secreted by organic anion transport and NSAIDs may compete for this pathway, but pivmecillinam is a short-course agent with a wide safety margin. No clinically important effect is expected.
How serious is the interaction between Celecoxib and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor renal function in patients with kidney impairment.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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