Drug interactions
Celecoxib + Pralatrexate
Severity: Moderate
Celecoxib and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal elimination of antifolates such as pralatrexate, raising systemic exposure and the risk of mucositis, myelosuppression and other toxicity. The risk is more relevant in patients with impaired renal function.
What this interaction means in plain words
Celecoxib and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAIDs reduce renal blood flow and may compete for renal tubular secretion, delaying pralatrexate clearance.
What to do
Monitor for mucositis and blood count changes and check renal function before and during treatment. Consider holding the NSAID or reducing the pralatrexate dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Celecoxib with Pralatrexate?
MediHelp rates the interaction as moderate. Celecoxib and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the renal elimination of antifolates such as pralatrexate, raising systemic exposure and the risk of mucositis, myelosuppression and other toxicity. The risk is more relevant in patients with impaired renal function.
How serious is the interaction between Celecoxib and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis and blood count changes and check renal function before and during treatment. Consider holding the NSAID or reducing the pralatrexate dose if toxicity develops.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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