Drug interactions
Celecoxib + Probenecid
Severity: Minor
Celecoxib and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal anion transport and may raise levels of many NSAIDs. For celecoxib, which is cleared mainly by hepatic metabolism, the effect is expected to be small, but probenecid may also inhibit CYP2C9 slightly.
What this interaction means in plain words
Celecoxib and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid may reduce renal tubular secretion and slightly inhibit metabolism of celecoxib.
What to do
No routine dose change is needed; watch for NSAID adverse effects such as dyspepsia or edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Celecoxib with Probenecid?
MediHelp rates the interaction as minor. Celecoxib and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid inhibits renal anion transport and may raise levels of many NSAIDs. For celecoxib, which is cleared mainly by hepatic metabolism, the effect is expected to be small, but probenecid may also inhibit CYP2C9 slightly.
How serious is the interaction between Celecoxib and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for NSAID adverse effects such as dyspepsia or edema.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
