Drug interactions
Celecoxib + Selexipag
Severity: Minor
Celecoxib and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is converted to its active metabolite partly by CYP2C8 and carboxylesterases, and CYP2C8 inhibitors raise exposure to the active metabolite. Celecoxib is not a recognised CYP2C8 inhibitor, so a meaningful interaction is unlikely.
What this interaction means in plain words
Celecoxib and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Selexipag belongs to Cardiovascular.
Why it happens
Proposed CYP2C8 inhibition by celecoxib, which is not well established.
What to do
No dose change is needed. Monitor for prostacyclin-type effects such as headache, jaw pain or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Celecoxib with Selexipag?
MediHelp rates the interaction as minor. Celecoxib and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selexipag is converted to its active metabolite partly by CYP2C8 and carboxylesterases, and CYP2C8 inhibitors raise exposure to the active metabolite. Celecoxib is not a recognised CYP2C8 inhibitor, so a meaningful interaction is unlikely.
How serious is the interaction between Celecoxib and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for prostacyclin-type effects such as headache, jaw pain or diarrhea.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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