Drug interactions
Celecoxib + Sparsentan
Severity: Moderate
Celecoxib and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can reduce renal function, which is a concern in patients with kidney disease who take sparsentan. Sparsentan may also induce CYP2C9 and lower celecoxib exposure, reducing its effect.
What this interaction means in plain words
Celecoxib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID-induced reduction in renal prostaglandins combines with dual endothelin/angiotensin blockade, and sparsentan induces CYP2C9 which metabolises celecoxib.
What to do
Monitor renal function, blood pressure and potassium during concurrent use, and avoid regular NSAID use where possible. Assess analgesic response and adjust therapy if celecoxib seems less effective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Sparsentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Celecoxib with Sparsentan?
MediHelp rates the interaction as moderate. Celecoxib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can reduce renal function, which is a concern in patients with kidney disease who take sparsentan. Sparsentan may also induce CYP2C9 and lower celecoxib exposure, reducing its effect.
How serious is the interaction between Celecoxib and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood pressure and potassium during concurrent use, and avoid regular NSAID use where possible. Assess analgesic response and adjust therapy if celecoxib seems less effective.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
