Drug interactions
Celecoxib + Thioridazine
Severity: Major
Celecoxib and Thioridazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a moderate CYP2D6 inhibitor and may raise thioridazine concentrations. Thioridazine is metabolized by CYP2D6 and causes dose-related QT prolongation, so higher levels raise the risk of torsades de pointes. Thioridazine labeling cautions against drugs that inhibit its metabolism.
What this interaction means in plain words
Celecoxib and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Celecoxib inhibits CYP2D6, reducing the metabolic clearance of thioridazine.
What to do
Avoid the combination where possible and choose an alternative analgesic. If used together, monitor ECG and electrolytes and consider reducing the thioridazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Celecoxib with Thioridazine?
MediHelp rates the interaction as major. Celecoxib and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Celecoxib is a moderate CYP2D6 inhibitor and may raise thioridazine concentrations. Thioridazine is metabolized by CYP2D6 and causes dose-related QT prolongation, so higher levels raise the risk of torsades de pointes. Thioridazine labeling cautions against drugs that inhibit its metabolism.
How serious is the interaction between Celecoxib and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative analgesic. If used together, monitor ECG and electrolytes and consider reducing the thioridazine dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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