Drug interactions
Celecoxib + Tolazamide
Severity: Minor
Celecoxib and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly enhance the glucose lowering of sulfonylureas, with a possible risk of hypoglycemia. Evidence is limited and the effect is generally small.
What this interaction means in plain words
Celecoxib and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Mechanism is not firmly established; possible effects on sulfonylurea metabolism via CYP2C9 or on glucose homeostasis.
What to do
Counsel patients on hypoglycemia symptoms and monitor blood glucose when starting or stopping celecoxib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Celecoxib with Tolazamide?
MediHelp rates the interaction as minor. Celecoxib and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may modestly enhance the glucose lowering of sulfonylureas, with a possible risk of hypoglycemia. Evidence is limited and the effect is generally small.
How serious is the interaction between Celecoxib and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on hypoglycemia symptoms and monitor blood glucose when starting or stopping celecoxib.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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