Drug interactions
Dalteparin + Tolfenamic acid
Severity: Major
Dalteparin and Tolfenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid is an NSAID that inhibits platelet aggregation and can cause gastrointestinal ulceration. With dalteparin the risk of bleeding is increased, particularly gastrointestinal bleeding.
What this interaction means in plain words
Dalteparin and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive effect on hemostasis through NSAID platelet inhibition and mucosal injury plus anticoagulation by dalteparin.
What to do
Prefer paracetamol or another non-NSAID analgesic. If the NSAID is necessary, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Dalteparin with Tolfenamic acid?
MediHelp rates the interaction as major. Dalteparin and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolfenamic acid is an NSAID that inhibits platelet aggregation and can cause gastrointestinal ulceration. With dalteparin the risk of bleeding is increased, particularly gastrointestinal bleeding.
How serious is the interaction between Dalteparin and Tolfenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic. If the NSAID is necessary, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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