Drug interactions
Celecoxib + Valproic acid
Severity: Minor
Celecoxib and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate can inhibit CYP2C9, which is the main metabolic route of celecoxib, so celecoxib levels may rise modestly. Both drugs may also affect platelet function and bleeding tendency. Clinically important effects are uncommon.
What this interaction means in plain words
Celecoxib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Valproic acid belongs to Central Nervous System.
Why it happens
Valproic acid inhibits CYP2C9-mediated celecoxib metabolism, with additive effects on platelet function.
What to do
No dose change is usually needed; monitor for NSAID adverse effects such as dyspepsia, edema or bleeding, especially with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Celecoxib with Valproic acid?
MediHelp rates the interaction as minor. Celecoxib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproate can inhibit CYP2C9, which is the main metabolic route of celecoxib, so celecoxib levels may rise modestly. Both drugs may also affect platelet function and bleeding tendency. Clinically important effects are uncommon.
How serious is the interaction between Celecoxib and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for NSAID adverse effects such as dyspepsia, edema or bleeding, especially with long-term use.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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