Drug interactions
Celecoxib + Vancomycin
Severity: Minor
Celecoxib and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of vancomycin, and this has chiefly been described in neonates. Higher vancomycin concentrations together with additive nephrotoxic potential could increase the risk of kidney injury. In healthy adults the effect is small.
What this interaction means in plain words
Celecoxib and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal perfusion and glomerular filtration decreases vancomycin elimination.
What to do
Monitor vancomycin trough or AUC-guided levels and serum creatinine, particularly in neonates and patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Celecoxib with Vancomycin?
MediHelp rates the interaction as minor. Celecoxib and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce renal clearance of vancomycin, and this has chiefly been described in neonates. Higher vancomycin concentrations together with additive nephrotoxic potential could increase the risk of kidney injury. In healthy adults the effect is small.
How serious is the interaction between Celecoxib and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vancomycin trough or AUC-guided levels and serum creatinine, particularly in neonates and patients with renal impairment.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
