Drug interactions
Celecoxib + Voclosporin
Severity: Moderate
Celecoxib and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can reduce GFR and cause nephrotoxicity. NSAIDs also impair renal hemodynamics, so combined use raises the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Celecoxib and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal vasoconstriction from calcineurin inhibition and NSAID prostaglandin inhibition.
What to do
Avoid regular NSAID use where possible and monitor eGFR, creatinine and potassium closely. Adjust voclosporin dosing per labeling if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Celecoxib with Voclosporin?
MediHelp rates the interaction as moderate. Celecoxib and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can reduce GFR and cause nephrotoxicity. NSAIDs also impair renal hemodynamics, so combined use raises the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Celecoxib and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and monitor eGFR, creatinine and potassium closely. Adjust voclosporin dosing per labeling if renal function declines.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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