Drug interactions
Celecoxib + Zafirlukast
Severity: Minor
Celecoxib and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP2C9 and could modestly raise celecoxib exposure. Clinically significant effects are unlikely, but GI or cardiovascular NSAID adverse effects are exposure-related.
What this interaction means in plain words
Celecoxib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast inhibits CYP2C9, the main metabolic pathway of celecoxib.
What to do
No adjustment is required; use the lowest effective celecoxib dose and monitor for GI and renal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Zafirlukast?
MediHelp rates the interaction as minor. Celecoxib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP2C9 and could modestly raise celecoxib exposure. Clinically significant effects are unlikely, but GI or cardiovascular NSAID adverse effects are exposure-related.
How serious is the interaction between Celecoxib and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; use the lowest effective celecoxib dose and monitor for GI and renal effects.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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