Drug interactions
Celiprolol + Digoxin
Severity: Moderate
Celiprolol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol, a beta-blocker, adds to digoxin's slowing of AV conduction and may cause bradycardia or heart block. Celiprolol may also modestly raise digoxin levels.
What this interaction means in plain words
Celiprolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and dromotropic effects; possible minor pharmacokinetic effect.
What to do
Monitor heart rate, ECG and digoxin levels, and reduce dose if bradycardia or conduction block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Celiprolol with Digoxin?
MediHelp rates the interaction as moderate. Celiprolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol, a beta-blocker, adds to digoxin's slowing of AV conduction and may cause bradycardia or heart block. Celiprolol may also modestly raise digoxin levels.
How serious is the interaction between Celiprolol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and digoxin levels, and reduce dose if bradycardia or conduction block occurs.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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