Drug interactions
Celiprolol + Hydrochlorothiazide
Severity: Minor
Celiprolol and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can reduce the oral absorption of celiprolol, lowering its exposure. Both agents lower blood pressure, so the net effect is usually still additive, but the beta-blocker effect may be less than expected.
What this interaction means in plain words
Celiprolol and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hydrochlorothiazide appears to reduce gastrointestinal absorption of celiprolol, possibly via transporter-mediated effects.
What to do
Monitor blood pressure and heart rate when starting or stopping either drug and adjust the celiprolol dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celiprolol and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Celiprolol with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Celiprolol and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can reduce the oral absorption of celiprolol, lowering its exposure. Both agents lower blood pressure, so the net effect is usually still additive, but the beta-blocker effect may be less than expected.
How serious is the interaction between Celiprolol and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping either drug and adjust the celiprolol dose if control is inadequate.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
