Drug interactions
Celiprolol + Metolazone
Severity: Minor
Celiprolol and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics may lower the absorption of celiprolol, potentially reducing its effect. Both agents lower blood pressure, so overall effect can still be additive.
What this interaction means in plain words
Celiprolol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced oral absorption of celiprolol has been reported with diuretics, with additive antihypertensive pharmacodynamics; mechanism not fully established.
What to do
Monitor blood pressure and heart rate when starting or stopping either drug and adjust the celiprolol dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Celiprolol with Metolazone?
MediHelp rates the interaction as minor. Celiprolol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics may lower the absorption of celiprolol, potentially reducing its effect. Both agents lower blood pressure, so overall effect can still be additive.
How serious is the interaction between Celiprolol and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping either drug and adjust the celiprolol dose if needed.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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