Drug interactions
Celiprolol + Sevoflurane
Severity: Moderate
Celiprolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane causes vasodilation and myocardial depression, and celiprolol, a beta-blocker, blunts reflex tachycardia. Hypotension and bradycardia may be more pronounced.
What this interaction means in plain words
Celiprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and negative chronotropic effects with attenuated compensatory sympathetic response.
What to do
Continue the beta-blocker perioperatively where indicated, monitor blood pressure and heart rate, and titrate the anesthetic. Keep vasopressors and atropine available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Celiprolol with Sevoflurane?
MediHelp rates the interaction as moderate. Celiprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane causes vasodilation and myocardial depression, and celiprolol, a beta-blocker, blunts reflex tachycardia. Hypotension and bradycardia may be more pronounced.
How serious is the interaction between Celiprolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the beta-blocker perioperatively where indicated, monitor blood pressure and heart rate, and titrate the anesthetic. Keep vasopressors and atropine available.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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