Drug interactions
Cenobamate + Colchicine
Severity: Moderate
Cenobamate and Colchicine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce colchicine concentrations, leading to reduced efficacy. Colchicine has a narrow therapeutic index, so dose changes should be careful.
What this interaction means in plain words
Cenobamate and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Colchicine belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by cenobamate increases colchicine metabolism.
What to do
Monitor for lack of colchicine effect and adjust the dose cautiously within labeled limits. Reassess dosing when cenobamate is stopped, because colchicine levels may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Colchicine?
MediHelp rates the interaction as moderate. Cenobamate and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce colchicine concentrations, leading to reduced efficacy. Colchicine has a narrow therapeutic index, so dose changes should be careful.
How serious is the interaction between Cenobamate and Colchicine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lack of colchicine effect and adjust the dose cautiously within labeled limits. Reassess dosing when cenobamate is stopped, because colchicine levels may rise.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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