Drug interactions
Cenobamate + Dantrolene
Severity: Moderate
Cenobamate and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate causes somnolence and dizziness, and dantrolene adds to sedation. Cenobamate is also a CYP3A4 inducer and may lower exposure to CYP3A4-metabolized drugs, although the importance of this for dantrolene is uncertain.
What this interaction means in plain words
Cenobamate and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression plus possible CYP3A4 induction by cenobamate, which may lower dantrolene exposure.
What to do
Monitor sedation and counsel the patient about driving. Assess dantrolene effectiveness and adjust the dose if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dantrolene?
MediHelp rates the interaction as moderate. Cenobamate and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate causes somnolence and dizziness, and dantrolene adds to sedation. Cenobamate is also a CYP3A4 inducer and may lower exposure to CYP3A4-metabolized drugs, although the importance of this for dantrolene is uncertain.
How serious is the interaction between Cenobamate and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel the patient about driving. Assess dantrolene effectiveness and adjust the dose if response is reduced.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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