Drug interactions
Cenobamate + Duloxetine
Severity: Moderate
Cenobamate and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, and duloxetine can add to these effects. Concurrent use may increase sedation and impair alertness. Cenobamate also induces some CYP enzymes, which is unlikely to affect duloxetine much.
What this interaction means in plain words
Cenobamate and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation, dizziness and impaired coordination, and advise caution with driving. Adjust doses if CNS effects become problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Duloxetine?
MediHelp rates the interaction as moderate. Cenobamate and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, and duloxetine can add to these effects. Concurrent use may increase sedation and impair alertness. Cenobamate also induces some CYP enzymes, which is unlikely to affect duloxetine much.
How serious is the interaction between Cenobamate and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and impaired coordination, and advise caution with driving. Adjust doses if CNS effects become problematic.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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