Drug interactions
Cenobamate + Ergotamine
Severity: Moderate
Cenobamate and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce ergotamine exposure, leading to reduced effect. Ergotamine dose escalation carries toxicity risk, so management is difficult.
What this interaction means in plain words
Cenobamate and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, increasing ergotamine clearance.
What to do
Monitor migraine response and consider a non-ergot alternative if efficacy falls. Avoid exceeding labeled ergotamine dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Ergotamine?
MediHelp rates the interaction as moderate. Cenobamate and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce ergotamine exposure, leading to reduced effect. Ergotamine dose escalation carries toxicity risk, so management is difficult.
How serious is the interaction between Cenobamate and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor migraine response and consider a non-ergot alternative if efficacy falls. Avoid exceeding labeled ergotamine dosing.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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