Drug interactions
Cenobamate + Esomeprazole
Severity: Moderate
Cenobamate and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19 and induces CYP3A4, so esomeprazole exposure may change in either direction. The net effect is uncertain, with CYP2C19 inhibition probably dominating.
What this interaction means in plain words
Cenobamate and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Cenobamate inhibits CYP2C19 and induces CYP3A4, altering esomeprazole metabolism.
What to do
Monitor acid suppression and adverse effects and adjust the esomeprazole dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Esomeprazole?
MediHelp rates the interaction as moderate. Cenobamate and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19 and induces CYP3A4, so esomeprazole exposure may change in either direction. The net effect is uncertain, with CYP2C19 inhibition probably dominating.
How serious is the interaction between Cenobamate and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor acid suppression and adverse effects and adjust the esomeprazole dose according to response.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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