Drug interactions
Esomeprazole + Mavacamten
Severity: Contraindicated
Esomeprazole and Mavacamten: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
What this interaction means in plain words
Esomeprazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Esomeprazole belongs to Gastrointestinal Tract; Mavacamten belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19-mediated metabolism of mavacamten increases its plasma concentrations.
What to do
Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Esomeprazole
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
- Dacomitinib + Esomeprazole Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Esomeprazole with Mavacamten?
MediHelp rates the interaction as contraindicated. Esomeprazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Esomeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
How serious is the interaction between Esomeprazole and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Esomeprazole page.
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