Drug interactions
Cenobamate + Everolimus
Severity: Moderate
Cenobamate and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower everolimus exposure, which may compromise antitumor, antiseizure or transplant efficacy.
What this interaction means in plain words
Cenobamate and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Everolimus belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4, accelerating everolimus clearance.
What to do
Monitor everolimus trough concentrations and clinical response, and increase the everolimus dose as needed. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Everolimus?
MediHelp rates the interaction as moderate. Cenobamate and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower everolimus exposure, which may compromise antitumor, antiseizure or transplant efficacy.
How serious is the interaction between Cenobamate and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical response, and increase the everolimus dose as needed. Reassess the dose if cenobamate is stopped.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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