Drug interactions
Cenobamate + Lacosamide
Severity: Moderate
Cenobamate and Lacosamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate may induce CYP3A4 and modestly reduce lacosamide exposure. Both drugs also act on sodium channels and can affect cardiac conduction, and both cause dizziness and somnolence.
What this interaction means in plain words
Cenobamate and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Lacosamide belongs to Central Nervous System.
Why it happens
Enzyme induction by cenobamate may increase lacosamide metabolism, with additive sodium-channel and conduction effects.
What to do
Monitor ECG when starting or titrating, particularly in patients with cardiac disease, and review seizure control. Adjust the lacosamide dose to clinical response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Lacosamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
- Eslicarbazepine + Lacosamide Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Lacosamide?
MediHelp rates the interaction as moderate. Cenobamate and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate may induce CYP3A4 and modestly reduce lacosamide exposure. Both drugs also act on sodium channels and can affect cardiac conduction, and both cause dizziness and somnolence.
How serious is the interaction between Cenobamate and Lacosamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when starting or titrating, particularly in patients with cardiac disease, and review seizure control. Adjust the lacosamide dose to clinical response and tolerability.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
