Drug interactions
Daridorexant + Lacosamide
Severity: Moderate
Daridorexant and Lacosamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, and combined use may increase somnolence, dizziness and next-day psychomotor impairment. This raises the risk of falls and impaired driving.
What this interaction means in plain words
Daridorexant and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lacosamide belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from orexin receptor antagonism and lacosamide's central effects.
What to do
Use the lowest effective daridorexant dose and counsel patients about daytime drowsiness and driving. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Eslicarbazepine + Lacosamide Moderate
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lacosamide?
MediHelp rates the interaction as moderate. Daridorexant and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, and combined use may increase somnolence, dizziness and next-day psychomotor impairment. This raises the risk of falls and impaired driving.
How serious is the interaction between Daridorexant and Lacosamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel patients about daytime drowsiness and driving. Reduce doses if excessive sedation occurs.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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