Drug interactions
Atazanavir + Lacosamide
Severity: Moderate
Atazanavir and Lacosamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong PR interval, so combined use may raise the risk of conduction abnormalities such as AV block. Atazanavir inhibits CYP3A4, which contributes to lacosamide clearance, though the pharmacokinetic effect is probably modest because several enzymes are involved.
What this interaction means in plain words
Atazanavir and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Lacosamide belongs to Central Nervous System.
Why it happens
Additive PR-interval prolongation, plus weak-to-moderate effect of CYP3A4 inhibition on lacosamide metabolism.
What to do
Obtain a baseline ECG and repeat after lacosamide reaches steady state, especially in patients with conduction disease or other PR-prolonging drugs. Reduce the lacosamide dose if bradycardia, dizziness or conduction delay develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Lacosamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
- Eslicarbazepine + Lacosamide Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Lacosamide?
MediHelp rates the interaction as moderate. Atazanavir and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong PR interval, so combined use may raise the risk of conduction abnormalities such as AV block. Atazanavir inhibits CYP3A4, which contributes to lacosamide clearance, though the pharmacokinetic effect is probably modest because several enzymes are involved.
How serious is the interaction between Atazanavir and Lacosamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after lacosamide reaches steady state, especially in patients with conduction disease or other PR-prolonging drugs. Reduce the lacosamide dose if bradycardia, dizziness or conduction delay develops.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Carbamazepine, Cenobamate. The full list is on the Lacosamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
