Drug interactions
Eslicarbazepine + Lacosamide
Severity: Moderate
Eslicarbazepine and Lacosamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on sodium channels, so combined use may add to dizziness, ataxia and PR prolongation or conduction block. Pharmacokinetic effects are small.
What this interaction means in plain words
Eslicarbazepine and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Lacosamide belongs to Central Nervous System.
Why it happens
Additive sodium channel blockade with additive effects on cardiac conduction and CNS.
What to do
Obtain an ECG at baseline and after lacosamide titration, especially with cardiac disease, and monitor for dizziness and diplopia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Eslicarbazepine with Lacosamide?
MediHelp rates the interaction as moderate. Eslicarbazepine and Lacosamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on sodium channels, so combined use may add to dizziness, ataxia and PR prolongation or conduction block. Pharmacokinetic effects are small.
How serious is the interaction between Eslicarbazepine and Lacosamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and after lacosamide titration, especially with cardiac disease, and monitor for dizziness and diplopia.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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