Drug interactions
Lacosamide + Zuranolone
Severity: Major
Lacosamide and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes pronounced somnolence and impaired driving ability. Lacosamide also causes dizziness and drowsiness, so combined psychomotor impairment may be greater.
What this interaction means in plain words
Lacosamide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lacosamide belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Reduce the zuranolone dose if excessive sedation occurs. Advise patients not to drive or use machinery for at least 12 hours after zuranolone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lacosamide
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
- Eslicarbazepine + Lacosamide Moderate
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Lacosamide with Zuranolone?
MediHelp rates the interaction as major. Lacosamide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes pronounced somnolence and impaired driving ability. Lacosamide also causes dizziness and drowsiness, so combined psychomotor impairment may be greater.
How serious is the interaction between Lacosamide and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zuranolone dose if excessive sedation occurs. Advise patients not to drive or use machinery for at least 12 hours after zuranolone.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Atazanavir, Carbamazepine, Cenobamate. The full list is on the Lacosamide page.
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