Drug interactions
Cenobamate + Mirtazapine
Severity: Moderate
Cenobamate and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower mirtazapine concentrations, potentially reducing its antidepressant effect. The effect is likely partial because mirtazapine has several metabolic routes.
What this interaction means in plain words
Cenobamate and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, increasing mirtazapine clearance.
What to do
Monitor depressive symptoms and increase the mirtazapine dose if response diminishes. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Mirtazapine?
MediHelp rates the interaction as moderate. Cenobamate and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower mirtazapine concentrations, potentially reducing its antidepressant effect. The effect is likely partial because mirtazapine has several metabolic routes.
How serious is the interaction between Cenobamate and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and increase the mirtazapine dose if response diminishes. Reassess the dose if cenobamate is stopped.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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