Drug interactions
Cenobamate + Modafinil
Severity: Moderate
Cenobamate and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and inhibits CYP2C19, so modafinil exposure may change in either direction. Net effect is uncertain and may alter alertness or adverse effects.
What this interaction means in plain words
Cenobamate and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Cenobamate induction of CYP3A4 and inhibition of CYP2C19, both involved in modafinil clearance.
What to do
Monitor wakefulness response and adverse effects when starting or stopping cenobamate. Adjust the modafinil dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Modafinil?
MediHelp rates the interaction as moderate. Cenobamate and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and inhibits CYP2C19, so modafinil exposure may change in either direction. Net effect is uncertain and may alter alertness or adverse effects.
How serious is the interaction between Cenobamate and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor wakefulness response and adverse effects when starting or stopping cenobamate. Adjust the modafinil dose according to response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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