Drug interactions
Cenobamate + Nevirapine
Severity: Major
Cenobamate and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 and CYP2B6 inducer and may reduce nevirapine concentrations. Lower levels risk virologic failure and resistance.
What this interaction means in plain words
Cenobamate and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cenobamate belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Cenobamate induces CYP3A4 and CYP2B6, increasing nevirapine clearance.
What to do
Monitor HIV viral load and nevirapine trough levels if available. Consider an alternative antiretroviral or antiseizure drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Nevirapine?
MediHelp rates the interaction as major. Cenobamate and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cenobamate is a CYP3A4 and CYP2B6 inducer and may reduce nevirapine concentrations. Lower levels risk virologic failure and resistance.
How serious is the interaction between Cenobamate and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and nevirapine trough levels if available. Consider an alternative antiretroviral or antiseizure drug.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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