Drug interactions
Cenobamate + Oxycodone
Severity: Moderate
Cenobamate and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower oxycodone concentrations, reducing analgesia. It is also sedating, so the two drugs add to CNS depression, and stopping cenobamate could raise oxycodone levels.
What this interaction means in plain words
Cenobamate and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by cenobamate reduces oxycodone exposure, combined with additive CNS depression.
What to do
Monitor pain control and titrate oxycodone as needed when cenobamate is started, and reduce the dose if cenobamate is withdrawn. Monitor for sedation throughout.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Oxycodone?
MediHelp rates the interaction as moderate. Cenobamate and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower oxycodone concentrations, reducing analgesia. It is also sedating, so the two drugs add to CNS depression, and stopping cenobamate could raise oxycodone levels.
How serious is the interaction between Cenobamate and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate oxycodone as needed when cenobamate is started, and reduce the dose if cenobamate is withdrawn. Monitor for sedation throughout.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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