Drug interactions
Cenobamate + Pregabalin
Severity: Moderate
Cenobamate and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents commonly cause somnolence, dizziness and impaired coordination. Combined use can intensify these effects, especially during titration.
What this interaction means in plain words
Cenobamate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate slowly and monitor for sedation, dizziness and ataxia. Reduce the dose of one agent if adverse effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Pregabalin?
MediHelp rates the interaction as moderate. Cenobamate and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents commonly cause somnolence, dizziness and impaired coordination. Combined use can intensify these effects, especially during titration.
How serious is the interaction between Cenobamate and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate slowly and monitor for sedation, dizziness and ataxia. Reduce the dose of one agent if adverse effects become troublesome.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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