Drug interactions
Cenobamate + Risperidone
Severity: Moderate
Cenobamate and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence and dizziness, and risperidone adds sedative and hypotensive effects. Cenobamate also induces CYP3A4, which could modestly reduce exposure to risperidone's active moiety.
What this interaction means in plain words
Cenobamate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression; cenobamate enzyme induction may lower risperidone levels.
What to do
Monitor for sedation, dizziness and falls, and reassess psychiatric response after cenobamate titration. Increase the risperidone dose only if loss of efficacy is evident.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Risperidone?
MediHelp rates the interaction as moderate. Cenobamate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence and dizziness, and risperidone adds sedative and hypotensive effects. Cenobamate also induces CYP3A4, which could modestly reduce exposure to risperidone's active moiety.
How serious is the interaction between Cenobamate and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and falls, and reassess psychiatric response after cenobamate titration. Increase the risperidone dose only if loss of efficacy is evident.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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