Drug interactions
Cenobamate + Ruxolitinib
Severity: Moderate
Cenobamate and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower ruxolitinib exposure. This may reduce control of myelofibrosis, polycythemia vera or graft-versus-host disease.
What this interaction means in plain words
Cenobamate and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by cenobamate increases ruxolitinib clearance.
What to do
Monitor blood counts and clinical response, and titrate ruxolitinib upward within labeled limits if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Ruxolitinib?
MediHelp rates the interaction as moderate. Cenobamate and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower ruxolitinib exposure. This may reduce control of myelofibrosis, polycythemia vera or graft-versus-host disease.
How serious is the interaction between Cenobamate and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response, and titrate ruxolitinib upward within labeled limits if efficacy is lost.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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