Drug interactions
Cenobamate + Trimipramine
Severity: Moderate
Cenobamate and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19, which contributes to tricyclic metabolism, so trimipramine exposure may rise. Both drugs also cause sedation, so drowsiness and dizziness may be worsened.
What this interaction means in plain words
Cenobamate and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by cenobamate plus additive CNS depression.
What to do
Consider a lower trimipramine dose and monitor for anticholinergic effects, sedation and cardiac effects. Titrate according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Trimipramine?
MediHelp rates the interaction as moderate. Cenobamate and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19, which contributes to tricyclic metabolism, so trimipramine exposure may rise. Both drugs also cause sedation, so drowsiness and dizziness may be worsened.
How serious is the interaction between Cenobamate and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower trimipramine dose and monitor for anticholinergic effects, sedation and cardiac effects. Titrate according to clinical response.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
