Drug interactions
Cephalexin + Hydrochlorothiazide
Severity: Minor
Cephalexin and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin and hydrochlorothiazide are both eliminated in part by tubular secretion, so competition might slightly alter exposure to either drug. Clinical relevance is limited in patients with normal renal function.
What this interaction means in plain words
Cephalexin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion.
What to do
No routine adjustment is needed; consider monitoring renal function and electrolytes in patients with kidney impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Cephalexin with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Cephalexin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin and hydrochlorothiazide are both eliminated in part by tubular secretion, so competition might slightly alter exposure to either drug. Clinical relevance is limited in patients with normal renal function.
How serious is the interaction between Cephalexin and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider monitoring renal function and electrolytes in patients with kidney impairment.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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