Drug interactions
Ceritinib + Clonidine
Severity: Major
Ceritinib and Clonidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can cause symptomatic bradycardia, and clonidine also lowers heart rate through central sympatholytic action. Together the risk of marked bradycardia and hypotension is increased.
What this interaction means in plain words
Ceritinib and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Clonidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic bradycardic effects.
What to do
Avoid the combination when possible; if needed, monitor heart rate and blood pressure regularly. For severe bradycardia, withhold ceritinib and reassess the clonidine dose; do not stop clonidine abruptly because of rebound hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Ceritinib with Clonidine?
MediHelp rates the interaction as major. Ceritinib and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib can cause symptomatic bradycardia, and clonidine also lowers heart rate through central sympatholytic action. Together the risk of marked bradycardia and hypotension is increased.
How serious is the interaction between Ceritinib and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if needed, monitor heart rate and blood pressure regularly. For severe bradycardia, withhold ceritinib and reassess the clonidine dose; do not stop clonidine abruptly because of rebound hypertension.
What other medicines interact with Ceritinib?
MediHelp also lists interactions of Ceritinib with, for example, Cisapride, Eletriptan, Flibanserin. The full list is on the Ceritinib page.
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