Drug interactions
Ceritinib + Darifenacin
Severity: Moderate
Ceritinib and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise darifenacin concentrations. This could increase anticholinergic adverse effects such as dry mouth, constipation and blurred vision.
What this interaction means in plain words
Ceritinib and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Darifenacin belongs to Genitourinary.
Why it happens
Ceritinib inhibits CYP3A4, reducing darifenacin metabolism.
What to do
Monitor for anticholinergic adverse effects and reduce the darifenacin dose if they occur. Keep darifenacin at the lowest effective dose during ceritinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Darifenacin?
MediHelp rates the interaction as moderate. Ceritinib and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise darifenacin concentrations. This could increase anticholinergic adverse effects such as dry mouth, constipation and blurred vision.
How serious is the interaction between Ceritinib and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the darifenacin dose if they occur. Keep darifenacin at the lowest effective dose during ceritinib therapy.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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