Drug interactions
Ceritinib + Diltiazem
Severity: Major
Ceritinib and Diltiazem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and can raise diltiazem levels, and both drugs slow heart rate and prolong cardiac conduction. The combination increases the risk of bradycardia, AV block and QT prolongation.
What this interaction means in plain words
Ceritinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP3A4 and adds to diltiazem's negative chronotropic effects.
What to do
Avoid if possible, and use an alternative antihypertensive or antiarrhythmic. If it is used, monitor heart rate, ECG and blood pressure and reduce the diltiazem dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Diltiazem?
MediHelp rates the interaction as major. Ceritinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4 and can raise diltiazem levels, and both drugs slow heart rate and prolong cardiac conduction. The combination increases the risk of bradycardia, AV block and QT prolongation.
How serious is the interaction between Ceritinib and Diltiazem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, and use an alternative antihypertensive or antiarrhythmic. If it is used, monitor heart rate, ECG and blood pressure and reduce the diltiazem dose as needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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